AVUE AvuePrep Plus - EDTA Solution 17% w/v for Irrigation

AvuePrep+17% Aqueous (EDTA) Solution

A liquid solution of ethylenediaminetetraacetic acid (EDTA) was thought to chemically soften the root canal dentine and dissolve the smear layer, as well as to increase dentine permeability.

AvuePrep+ is a polyaminocarboxylic acid and a colorless, water-soluble solid. It is widely used to dissolve lime scale. Its usefulness arises because of its role as a hexadentate ligand and chelating agent, i.e. its ability to sequester metal ions such as Ca²⁺ and Fe³⁺.

The compound was first described in 1935 by Ferdinand Munz, who prepared the compound from ethylene diamine and chloroacetic acid. Nowadays, EDTA is mainly synthesized from ethylene diamine, formaldehyde and sodium cyanide.

Almost all manufacturers of nickel-titanium instruments recommend their use as a lubricant during rotary root canal preparation. Additionally, a final irrigation of the root canal with 17% EDTA AvuePrep+ solutions to dissolve the smear layer is recommended.

1. Help to remove debris,organic/inorganic tissues during irrigation
2. Makes it easier to remove debris.
3. Helps to enlarge and shape the canal for final filling.
4. Makes easy for instrumentation.
5. Irrigating agent during root canal cleaning.
6. Helps to declacify the dentin.

Irrigation solution help to remove smear layer

The use of 17% EDTA resulted in the greatest concentration of calcium ions compared with other chelating agents. Avueprep+ was the most efficient solution for removal of smear layer.

Antimicrobial activity

The antibacterial activity of Avueprep+ is due to the chelation of cations from the outer membrane of bacteria.

Effects on Dentin microhardness

EDTA reduce the root dentine microhardness, whereby the greatest differences are to be found in dentine immediately adjacent to the root canal lumen. After 3 min, EDTA produced a greater reduction in microhardness.

After removing smear layer adhesion of root canal sealer increases

Treating dentine with a combination of NaOCl and  EDTA produced stronger adhesion of resin based sealer compared to NaOCl alone.

AvuePrep+ and AvuePrep cause no inflammatory reaction 

It has been proven that even if EDTA is forced through the apical foramen into the periapical tissues, no periapical tissue damage could be detected after 14 months. Furthermore, that placement of EDTA for 28 days after pulpotomy produced no pulpal tissue necrosis. However, changes in macrophage activity can cause the inflammatory reaction to be more easily initiated, but reduced capacity of phagocytosis can result. Furthermore, EDTA improves plasma extravasation and mediator action. 

Better to use Avueprep+ with sodium hypochlorite during irrigation

It has been revealed that using 17% EDTA or NaOCl alone as irrigants did not remove calcium hydroxide from the root canal, but combining these two irrigants with hand instrumentation improved the effectiveness of the removal.

Action of AvuePrep+