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AVUE AvuePrep Plus - EDTA Solution 17% w/v for Irrigation
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AvuePrep+17% Aqueous (EDTA) Solution
A liquid solution of ethylenediaminetetraacetic acid (EDTA) was thought to chemically soften the root canal dentine and dissolve the smear layer, as well as to increase dentine permeability.
AvuePrep+is a polyaminocarboxylic acid and a colorless, water-soluble solid. It is widely used to dissolve lime scale. Its usefulness arises because of its role as a hexadentate ligand and chelating agent, i.e. its ability to sequester metal ions such as Ca2+ and Fe3+.
The compound was first described in 1935 by Ferdinand Munz, who prepared the compound from ethylene diamine and chloroacetic acid. Nowadays, EDTA is mainly synthesized from ethylene diamine, formaldehyde and sodium cyanide.
Almost all manufacturers of nickel-titanium instruments recommend their use as a lubricant during rotary root canal preparation. Additionally, a final irrigation of the root canal with 17% EDTA AvuePrep+solutions to dissolve the smear layer is recommended.
1. Help to remove debris,organic/inorganic tissues during irrigation
2. Makes it easier to remove debris.
3. Helps to enlarge and shape the canal for final filling.
4. Makes easy for instrumentation.
5. Irrigating agent during root canal cleaning.
6. Helps to declacify the dentin.
Irrigation solution help to remove smear layer
The use of 17% EDTA resulted in the greatest concentration of calcium ions compared with other chelating agents. Avueprep+was the most efficient solution for removal of smear layer.
Antimicrobial activity
The antibacterial activity of Avueprep+is due to the chelation of cations from the outer membrane of bacteria.
Effects on Dentin microhardness
EDTA reduce the root dentine microhardness, whereby the greatest differences are to be found in dentine immediately adjacent to the root canal lumen. After 3 min, EDTA produced a greater reduction in microhardness.
After removing smear layer adhesion of root canal sealer increases
Treating dentine with a combination of NaOCl and EDTA produced stronger adhesion of resin based sealer compared to NaOCl alone.
AvuePrep+ and AvuePrep cause no inflammatory reaction
It has been proven that even if EDTA is forced through the apical foramen into the periapical tissues, no periapical tissue damage could be detected after 14 months. Furthermore, that placement of EDTA for 28 days after pulpotomy produced no pulpal tissue necrosis. However, changes in macrophage activity can cause the inflammatory reaction to be more easily initiated, but reduced capacity of phagocytosis can result. Furthermore, EDTA improves plasma extravasation and mediator action.
Better to use Avueprep+ with sodium hypochlorite during irrigation
It has been revealed that using 17% EDTA or NaOCl alone as irrigants did not remove calcium hydroxide from the root canal, but combining these two irrigants with hand instrumentation improved the effectiveness of the removal.
Action of AvuePrep+
AvuePrep+ helps to decalcify the dentin in the canal wall2. Blockage of root canal.
3. Calcified obstructions.
1. Prepare the Access Cavity.
2. Fill the canal with Avueprep plus syringe.
3. Start with cleaning and shaping of Root canal.
4. Reapply Avueprep plus as necessary for Irrigation until canal is enlarged to the desired size.
5. Finally rinse the canal with the Irrigant of choice.
Storage
Store in a cool and dry place.
key Features
1. Helps decalcify the dentin.
2. Makes it easier to remove debris.
3. Helps to enlarge and shape the canal for final filling.
4. Makes easy for instrumentation.
5. Irrigating agent.